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Heterologous Expression Studies of Saccharomyces cerevisiae Reveal Two Distinct Trypanosomatid CaaX Protease Activities and Identify Their Potential Targets

The CaaX tetrapeptide motif typically directs three sequential posttranslational modifications, namely, isoprenylation, proteolysis, and carboxyl methylation. In all eukaryotic systems evaluated to date, two CaaX proteases (Rce1 and Ste24/Afc1) have been identified. Although the Trypanosoma brucei g...

詳細記述

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書誌詳細
主要な著者: Mokry, David Z., Manandhar, Surya P., Chicola, Kristen A., Santangelo, George M., Schmidt, Walter K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794219/
https://ncbi.nlm.nih.gov/pubmed/19820121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00169-09
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