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Sub-cellular trafficking and functionality of 2′-O-methyl and 2′-O-methyl-phosphorothioate molecular beacons

Molecular beacons (MBs) have shown great potential for the imaging of RNAs within single living cells; however, the ability to perform accurate measurements of RNA expression can be hampered by false-positives resulting from nonspecific interactions and/or nuclease degradation. These false-positives...

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Détails bibliographiques
Auteurs principaux: Chen, Antony K., Behlke, Mark A., Tsourkas, Andrew
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794186/
https://ncbi.nlm.nih.gov/pubmed/19820111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp837
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