DNA Methyltransferase Protein Synthesis Is Reduced in CXXC Finger Protein 1–Deficient Embryonic Stem Cells

CXXC finger protein 1 (CFP1) binds to unmethylated CpG dinucleotides and is required for embryogenesis. CFP1 is also a component of the Setd1A and Setd1B histone H3K4 methyltransferase complexes. Murine embryonic stem (ES) cells lacking CFP1 fail to differentiate, and exhibit a 70% reduction in glob...

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Detalhes bibliográficos
Main Authors: Butler, Jill S., Palam, Lakshmi R., Tate, Courtney M., Sanford, Jeremy R., Wek, Ronald C., Skalnik, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793591/
https://ncbi.nlm.nih.gov/pubmed/19388845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2009.0854
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