Mitochondrial Complex II Dysfunction Can Contribute Significantly to Genomic Instability after Exposure to Ionizing Radiation

Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radiation-induced mutator phenotype, end points of mit...

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Detalhes bibliográficos
Main Authors: Dayal, Disha, Martin, Sean M., Owens, Kjerstin M., Aykin-Burns, Nukhet, Zhu, Yueming, Boominathan, Amutha, Pain, Debkumar, Limoli, Charles L., Goswami, Prabhat C., Domann, Frederick E., Spitz, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793528/
https://ncbi.nlm.nih.gov/pubmed/19929420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR1617.1
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