The Calpain, Caspase 12, Caspase 3 Cascade Leading to Apoptosis Is Altered in F508del-CFTR Expressing Cells

In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER). We previously showed that the unfolded protein response (UPR) may be triggered in CF. Since...

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Bibliographic Details
Main Authors: Kerbiriou, Mathieu, Teng, Ling, Benz, Nathalie, Trouvé, Pascal, Férec, Claude
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793515/
https://ncbi.nlm.nih.gov/pubmed/20041182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008436
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