Improvement of Chloride Transport Defect by Gonadotropin-Releasing Hormone (GnRH) in Cystic Fibrosis Epithelial Cells

Cystic fibrosis (CF), the most common autosomal recessive disease in Caucasians, is due to mutations in the CFTR gene. F508del, the most frequent mutation in patients, impairs CFTR protein folding and biosynthesis. The F508del-CFTR protein is retained in the endoplasmic reticulum (ER) and its traffi...

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Dettagli Bibliografici
Autori principali: Benz, Nathalie, Le Hir, Sophie, Norez, Caroline, Kerbiriou, Mathieu, Calvez, Marie-Laure, Becq, Frédéric, Trouvé, Pascal, Férec, Claude
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929654/
https://ncbi.nlm.nih.gov/pubmed/24586461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088964
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