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Myosin IXa Regulates Epithelial Differentiation and Its Deficiency Results in Hydrocephalus

The ependymal multiciliated epithelium in the brain restricts the cerebrospinal fluid to the cerebral ventricles and regulates its flow. We report here that mice deficient for myosin IXa (Myo9a), an actin-dependent motor molecule with a Rho GTPase–activating (GAP) domain, develop severe hydrocephalu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Abouhamed, Marouan, Grobe, Kay, Leefa Chong San, Isabelle V., Thelen, Sabine, Honnert, Ulrike, Balda, Maria S., Matter, Karl, Bähler, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793285/
https://ncbi.nlm.nih.gov/pubmed/19828736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-04-0291
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