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Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall

All forms of chronic pulmonary hypertension (PH) are characterized by structural remodeling of the pulmonary artery (PA) media, a process previously attributed solely to changes in the phenotype of resident smooth muscle cells (SMC). However, recent experimental evidence in both systemic and pulmona...

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Detalhes bibliográficos
Main Authors: Frid, Maria G., Li, Min, Gnanasekharan, Meena, Burke, Danielle L., Fragoso, Miguel, Strassheim, Derek, Sylman, Joanna L., Stenmark, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793191/
https://ncbi.nlm.nih.gov/pubmed/19767409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90611.2008
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