Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1

Patients with acute lung injury develop hypoxia, which may lead to lung dysfunction and aberrant tissue repair. Recent studies have suggested that epithelial-mesenchymal transition (EMT) contributes to pulmonary fibrosis. We sought to determine whether hypoxia induces EMT in alveolar epithelial cell...

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Detalhes bibliográficos
Main Authors: Zhou, Guofei, Dada, Laura A., Wu, Minghua, Kelly, Aileen, Trejo, Humberto, Zhou, Qiyuan, Varga, John, Sznajder, Jacob I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793183/
https://ncbi.nlm.nih.gov/pubmed/19801454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00007.2009
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