Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA PI3K

Class IA (p85/p110) PI 3-kinases play a major role in regulating cell growth, survival, and motility. Activating mutations in the p110α isoform of the class IA catalytic subunit (PIK3CA) are commonly found in human cancers. These mutations lead to increased proliferation and transformation in cultur...

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Главные авторы: Pang, Huan, Flinn, Rory, Patsialou, Antonia, Wyckoff, Jeffrey, Roussos, Evanthia T., Wu, Haiyan, Pozzutto, Maria, Goswami, Sumanta, Condeelis, John S., Bresnick, Anne R., Segall, Jeffrey E., Backer, Jonathan M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793177/
https://ncbi.nlm.nih.gov/pubmed/19903845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1968
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