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Selection and Characterization of Small Molecules That Bind the HIV-1 Frameshift Site RNA

HIV-1 requires a −1 translational frameshift to properly synthesize the viral enzymes required for replication. The frameshift mechanism is dependent upon two RNA elements, a seven-nucleotide slippery sequence (UUUUUUA) and a downstream RNA structure. Frameshifting occurs with a frequency of ~5%, an...

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Detalhes bibliográficos
Main Authors: Marcheschi, Ryan J., Mouzakis, Kathryn D., Butcher, Samuel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792117/
https://ncbi.nlm.nih.gov/pubmed/19673541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900167m
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