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Selection and Characterization of Small Molecules That Bind the HIV-1 Frameshift Site RNA
HIV-1 requires a −1 translational frameshift to properly synthesize the viral enzymes required for replication. The frameshift mechanism is dependent upon two RNA elements, a seven-nucleotide slippery sequence (UUUUUUA) and a downstream RNA structure. Frameshifting occurs with a frequency of ~5%, an...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2792117/ https://ncbi.nlm.nih.gov/pubmed/19673541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900167m |
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