Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

CD4(+) T cells producing interleukin-10 (IL-10) and interferon-γ (IFN-γ) are reported in chronic infections. However, the signals that direct the development of IL-10-producing T helper 1 (Th1) cells are undefined. We showed that development of IL-10-producing Th1 cells required high T cell receptor...

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Main Authors: Saraiva, Margarida, Christensen, Jillian R., Veldhoen, Marc, Murphy, Theresa L., Murphy, Kenneth M., O'Garra, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791889/
https://ncbi.nlm.nih.gov/pubmed/19646904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.05.012
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