Abnormal Expression of Collagen IV in Lens Activates Unfolded Protein Response Resulting in Cataract

Human diseases caused by mutations in extracellular matrix genes are often associated with an increased risk of cataract and lens capsular rupture. However, the underlying mechanisms of cataract pathogenesis in these conditions are still unknown. Using two different mouse models, we show that the ac...

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Bibliographic Details
Main Authors: Firtina, Zeynep, Danysh, Brian P., Bai, Xiaoyang, Gould, Douglas B., Kobayashi, Takehiro, Duncan, Melinda K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791016/
https://ncbi.nlm.nih.gov/pubmed/19858219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.060384
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