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Genetic Ablation of Calcium-independent Phospholipase A(2)γ Leads to Alterations in Hippocampal Cardiolipin Content and Molecular Species Distribution, Mitochondrial Degeneration, Autophagy, and Cognitive Dysfunction
Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) results in profound alterations in hippocampal phospholipid metabolism and mitochondrial phospholipid homeostasis resulting in enlarged and degenerating mitochondria leading to autophagy and cognitive dysfunction. Shotgun lipidom...
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| Autors principals: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790994/ https://ncbi.nlm.nih.gov/pubmed/19840936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055194 |
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