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Genetic Ablation of Calcium-independent Phospholipase A(2)γ Leads to Alterations in Hippocampal Cardiolipin Content and Molecular Species Distribution, Mitochondrial Degeneration, Autophagy, and Cognitive Dysfunction

Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) results in profound alterations in hippocampal phospholipid metabolism and mitochondrial phospholipid homeostasis resulting in enlarged and degenerating mitochondria leading to autophagy and cognitive dysfunction. Shotgun lipidom...

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Autors principals: Mancuso, David J., Kotzbauer, Paul, Wozniak, David F., Sims, Harold F., Jenkins, Christopher M., Guan, Shaoping, Han, Xianlin, Yang, Kui, Sun, Gang, Malik, Ibrahim, Conyers, Sara, Green, Karen G., Schmidt, Robert E., Gross, Richard W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790994/
https://ncbi.nlm.nih.gov/pubmed/19840936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055194
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