PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

INTRODUCTION: Alterations in cell cycle regulators have been implicated in human malignancies including breast cancer. PD 0332991 is an orally active, highly selective inhibitor of the cyclin D kinases (CDK)4 and CDK6 with ability to block retinoblastoma (Rb) phosphorylation in the low nanomolar ran...

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Bibliographic Details
Main Authors: Finn, Richard S, Dering, Judy, Conklin, Dylan, Kalous, Ondrej, Cohen, David J, Desai, Amrita J, Ginther, Charles, Atefi, Mohammad, Chen, Isan, Fowst, Camilla, Los, Gerret, Slamon, Dennis J
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790859/
https://ncbi.nlm.nih.gov/pubmed/19874578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2419
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