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Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn(2+)-dependent deoxyribozymes that use 2′,3′-cyclic phosphate RNA substrates
Our previous efforts have used in vitro selection to identify numerous Zn(2+)-dependent deoxyribozymes that ligate two RNA substrates with reaction at a 2′,3′-cyclic phosphate. Each deoxyribozyme creates one of several different RNA linkages, including native 3′–5′ and non-native 2′–5′ phosphodieste...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790812/ https://ncbi.nlm.nih.gov/pubmed/19005599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b813566e |
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