Hematopoietic cell specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high fat fed mice

Chronic, low-grade inflammation, particularly in adipose tissue, is an important modulator of obesity-induced insulin resistance and the toll-like receptor 4 (Tlr4) is a key initiator of inflammatory responses in macrophages. We performed bone marrow transplantation (BMT) of Tlr4lps-del or control C...

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Main Authors: Saberi, Maziyar, Woods, Niels-Bjarne, de Luca, Carl, Schenk, Simon, Lu, Juu Chin, Bandyopadhyay, Gautam, Verma, Inder M., Olefsky, Jerrold M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790319/
https://ncbi.nlm.nih.gov/pubmed/19883619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.09.006
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