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Acute but not chronic Donepezil administration increases muscarinic receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats
Donepezil, an acetylcholinesterase (AChE) inhibitor that is used to treat patients with Alzheimer’s disease, is thought to act by increasing brain extracellular acetylcholine (ACh), and thus ACh binding to cholinergic receptors. Cholinergic muscarinic receptors may be coupled to cytosolic phospholip...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790024/ https://ncbi.nlm.nih.gov/pubmed/19363262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1058 |
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