Effects of muscarinic receptor stimulation on Ca(2+) transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells

We investigated the contribution of the intracellular calcium (Ca(i)(2+)) transient to acetylcholine (ACh)-mediated reduction of pacemaker frequency and cAMP content in rabbit sinoatrial nodal (SAN) cells. Action potentials (whole cell perforated patch clamp) and Ca(i)(2+) transients (Indo-1 fluores...

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Autors principals: van Borren, Marcel M. G. J., Verkerk, Arie O., Wilders, Ronald, Hajji, Najat, Zegers, Jan G., Bourier, Jan, Tan, Hanno L., Verheijck, Etienne E., Peters, Stephan L. M., Alewijnse, Astrid E., Ravesloot, Jan-Hindrik
Format: Artigo
Idioma:Inglês
Publicat: D. Steinkopff-Verlag 2009
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Original Contribution
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789936/
https://ncbi.nlm.nih.gov/pubmed/19639379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-009-0048-9
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