Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial

Cholesterol homeostasis, defined as the balance between absorption and synthesis, influences circulating cholesterol concentrations and subsequent coronary heart disease (CHD) risk. Statin therapy targets the rate-limiting enzyme in cholesterol biosynthesis and is efficacious in lowering CHD events...

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Main Authors: Matthan, Nirupa R., Resteghini, Nancy, Robertson, Michele, Ford, Ian, Shepherd, James, Packard, Chris, Buckley, Brendan M., Jukema, J. Wouter, Lichtenstein, Alice H., Schaefer, Ernst J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2010
Fag:
Patient-Oriented and Epidemiological Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789780/
https://ncbi.nlm.nih.gov/pubmed/19578163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M900032-JLR200
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