Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background

Matrix metalloproteinases (MMPs) are a family of enzymes with a myriad of functions. Lately we have come to realize that broad-spectrum inhibition of these enzymes, as was tried unsuccessfully in multiple phase III trials in cancer patients, is likely unwise given the pro- and anti-tumorigenic funct...

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Hauptverfasser: Martin, Michelle D., Carter, Kathy J., Jean-Philippe, Sharon R., Chang, Mayland, Mobashery, Shahriar, Thiolloy, Sophie, Lynch, Conor C., Matrisian, Lynn M., Fingleton, Barbara
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789265/
https://ncbi.nlm.nih.gov/pubmed/18676849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0537
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