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Opposing Effects of KLF5 on the Transcription of MYC in Epithelial Proliferation in the Context of Transforming Growth Factor β

The proto-oncogene MYC plays a critical role in cell proliferation and tumorigenesis, and its down-regulation by transforming growth factor β (TGFβ) signaling is necessary for TGFβ to inhibit cell proliferation. KLF5, on the other hand, is a pro-proliferative basic transcription factor that reverses...

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Autors principals: Guo, Peng, Dong, Xue-Yuan, Zhao, Kewen, Sun, Xiaodong, Li, Qunna, Dong, Jin-Tang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788876/
https://ncbi.nlm.nih.gov/pubmed/19684017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036160
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