Akt Increases Sarcoplasmic Reticulum Ca(2+) Cycling by Direct Phosphorylation of Phospholamban at Thr(17)

Cardiomyocytes adapt to physical stress by increasing their size while maintaining cell function. The serine/threonine kinase Akt plays a critical role in this process of adaptation. We previously reported that transgenic overexpression of an active form of Akt (Akt-E40K) in mice results in increase...

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Main Authors: Catalucci, Daniele, Latronico, Michael V. G., Ceci, Marcello, Rusconi, Francesca, Young, Howard S., Gallo, Paolo, Santonastasi, Marco, Bellacosa, Alfonso, Brown, Joan Heller, Condorelli, Gianluigi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788869/
https://ncbi.nlm.nih.gov/pubmed/19696029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036566
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