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Absence of Direct Cyclic Nucleotide Modulation of mEAG1 and hERG1 Channels Revealed with Fluorescence and Electrophysiological Methods

Similar to CNG and HCN channels, EAG and ERG channels contain a cyclic nucleotide binding domain (CNBD) in their C terminus. While cyclic nucleotides have been shown to facilitate opening of CNG and HCN channels, their effect on EAG and ERG channels is less clear. Here we explored cyclic nucleotide...

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Détails bibliographiques
Auteurs principaux: Brelidze, Tinatin I., Carlson, Anne E., Zagotta, William N.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788851/
https://ncbi.nlm.nih.gov/pubmed/19671703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016337
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