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Discovery of Dermorphin-Based Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors

A series of potent electrophilic affinity labels (IC(50) = 0.1-5 nM) containing either a bromoacetamide or isothiocyanate based on the mu opioid receptor (MOR) selective peptide dermorphin were prepared. All four analogs exhibited wash resistant inhibition of [(3)H]DAMGO binding at subnanomolar to n...

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Bibliografiske detaljer
Main Authors: Sinha, Bhaswati, Cao, Zhengyu, Murray, Thomas F., Aldrich, Jane V.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788677/
https://ncbi.nlm.nih.gov/pubmed/19621878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9007592
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