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Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
BACKGROUND: The tumor suppressor protein p53 is regulated by the ubiquitin ligase MDM2 which down-regulates p53. In tumours with overexpressed MDM2, the p53-MDM2 interaction can be interrupted by a peptide or small molecule to stabilize p53 as a therapeutic strategy. Structural and biochemical/mutag...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788357/ https://ncbi.nlm.nih.gov/pubmed/19958516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S15-S6 |
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