Structural model of ρ1 GABA(C) receptor based on evolutionary analysis: Testing of predicted protein–protein interactions involved in receptor assembly and function

The homopentameric ρ1 GABA(C) receptor is a ligand-gated ion channel with a binding pocket for γ-aminobutyric acid (GABA) at the interfaces of N-terminal extracellular domains. We combined evolutionary analysis, structural modeling, and experimental testing to study determinants of GABA(C) receptor...

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Detalhes bibliográficos
Main Authors: Adamian, Larisa, Gussin, Hélène A, Tseng, Yan Yuan, Muni, Niraj J, Feng, Feng, Qian, Haohua, Pepperberg, David R, Liang, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788291/
https://ncbi.nlm.nih.gov/pubmed/19768800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.247
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