Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

BACKGROUND: The mitotic arrest deficiency protein 2 (MAD2) is a key component of the mitotic spindle assembly checkpoint, monitoring accurate chromosomal alignment at the metaphase plate before mitosis. MAD2 also has a function in cellular senescence and in a cell's response to microtubule inhi...

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Detalhes bibliográficos
Main Authors: Prencipe, M, Fitzpatrick, P, Gorman, S, Mosetto, M, Klinger, R, Furlong, F, Harrison, M, O'Connor, D, Roninson, I B, O'Sullivan, J, McCann, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788249/
https://ncbi.nlm.nih.gov/pubmed/19935801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605419
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