Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells

Annually, ovarian cancer (OC) affects 240,000 women worldwide and is the most lethal gynecological malignancy. High-grade serous OC (HGSOC) is the most common and aggressive OC subtype, characterized by widespread genome changes and chromosomal instability and is consequently poorly responsive to ch...

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Veröffentlicht in:Cancer Med
Hauptverfasser: Weiner-Gorzel, Karolina, Dempsey, Eugene, Milewska, Malgorzata, McGoldrick, Aloysius, Toh, Valerie, Walsh, Aoibheann, Lindsay, Sinead, Gubbins, Luke, Cannon, Aoife, Sharpe, Daniel, O'Sullivan, Jacintha, Murphy, Madeline, Madden, Stephen F, Kell, Malcolm, McCann, Amanda, Furlong, Fiona
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430267/
https://ncbi.nlm.nih.gov/pubmed/25684390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.409
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