Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin signaling

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is accompanied by collagen crosslinking, ECM stiffening and increased focal adhes...

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Главные авторы: Levental, Kandice R., Yu, Hongmei, Kass, Laura, Lakins, Johnathon N., Egeblad, Mikala, Erler, Janine T., Fong, Sheri F.T., Csiszar, Katalin, Giaccia, Amato, Weninger, Wolfgang, Yamauchi, Mitsuo, Gasser, David L., Weaver, Valerie M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788004/
https://ncbi.nlm.nih.gov/pubmed/19931152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.10.027
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