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Spontaneous mutation in the Cd79b gene leads to a block in B lymphocyte development at the C′ (early pre-B) stage

We discovered B lymphocyte deficient mice within a group of B10.A-CD45.1 mice, and established that this deficiency was a recessively inherited trait. Gene mapping and sequence analysis showed a mutation in the 3(rd) exon of the Cd79b gene (c.224G>A) that leads to the generation of a stop codon (...

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Bibliografiset tiedot
Päätekijät: Shulzhenko, Natalia, Morgun, Andrey, Matzinger, Polly
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787784/
https://ncbi.nlm.nih.gov/pubmed/19727123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2009.70
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