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The i-Motif in the bcl-2 P1 Promoter Forms an Unexpectedly Stable Structure with a Unique 8:5:7 Loop Folding Pattern

Transcriptional regulation of the bcl-2 proto-oncogene is highly complex, with the majority of transcription driven by the P1 promoter site and the interaction of multiple regulatory proteins. A guanine- and cytosine-rich (GC-rich) region directly upstream of the P1 site has been shown to be integra...

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Detalhes bibliográficos
Main Authors: Kendrick, Samantha, Akiyama, Yoshitsugu, Hecht, Sidney M., Hurley, Laurence H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787777/
https://ncbi.nlm.nih.gov/pubmed/19908860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9076292
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