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Embryonic Stem Cells Lacking the Epigenetic Regulator Cfp1 are Hypersensitive to DNA-Damaging Agents and Exhibit Decreased Ape1/Ref-1 Protein Expression and Endonuclease Activity
Modulation of chromatin structure plays an important role in the recruitment and function of DNA repair proteins. CXXC finger protein 1 (Cfp1), encoded by the CXXC1 gene, is essential for mammalian development and is an important regulator of chromatin structure. Murine embryonic stem (ES) cells lac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787775/ https://ncbi.nlm.nih.gov/pubmed/19836314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.09.011 |
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