A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence

Poly(ADP-ribose) polymerases (PARPs) convert NAD to polymers of ADP-ribose that are converted to free ADP-ribose by poly(ADP-ribose) glycohydrolase (PARG). The activation of the nuclear enzyme PARP-1 following genotoxic stress has been linked to release of apoptosis inducing factor from the mitochon...

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Autores principales: Whatcott, Clifford J., Meyer-Ficca, Mirella L., Meyer, Ralph G., Jacobson, Myron K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787692/
https://ncbi.nlm.nih.gov/pubmed/19389396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.04.005
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