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The Role of Hydrophobic and Negatively Charged Surface Patches of Lipid-Free Apolipoprotein A-I in Lipid Binding and ABCA1-Mediated Cholesterol Efflux
Recent models of lipid-free apolipoprotein A-I, including a cross-link/homology model and an x-ray crystal structure have identified two potential functionally relevant “patches” on the protein surface. The first is a hydrophobic surface patch composed of leucine residues 42, 44, 46, and 47 and the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787660/ https://ncbi.nlm.nih.gov/pubmed/19782154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2009.09.012 |
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