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Convergent Synthesis of Stereodefined Exo-alkylidene-γ-Lactams from β-Halo Allylic Alcohols

[Image: see text] A convergent process for the assembly of stereodefined mono- and bicyclic exo-alkylidene γ-lactams is described that proceeds through the union of β-halo allylic alcohols, aromatic imines and CO. Overall, regio- and stereoselective Ti-mediated reductive cross-coupling, followed by...

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Autors principals: Umemura, Shuhei, McLaughlin, Martin, Micalizio, Glenn C.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787655/
https://ncbi.nlm.nih.gov/pubmed/19877599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol9022134
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