A Phase I Study of Flavopiridol Administered with Oxaliplatin and Fluorouracil/Leucovorin (FOLFOX) in Advanced Solid Tumors: Encouraging Activity in Refractory Germ Cell Tumors

PURPOSE: Flavopiridol, a cyclin-dependent kinase inhibitor, has promising clinical activity when combined with chemotherapy. Preclinical data indicate that flavopiridol enhances oxaliplatin (OX)- and fluorouracil (5FU)-induced apoptosis in a sequence-dependent manner. EXPERIMENTAL DESIGN: We conduct...

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Detalhes bibliográficos
Main Authors: Rathkopf, Dana, Dickson, Mark A., Feldman, Darren R., Carvajal, Richard D., Shah, Manish A., Wu, Nian, Lefkowitz, Robert, Gonen, Mithat, Cane, Lauren M., Dials, Heather J., Winkelmann, Jennifer L., Bosl, George J., Schwartz, Gary K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787644/
https://ncbi.nlm.nih.gov/pubmed/19934304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1502
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