A Phase I Study of Flavopiridol Administered with Oxaliplatin and Fluorouracil/Leucovorin (FOLFOX) in Advanced Solid Tumors: Encouraging Activity in Refractory Germ Cell Tumors

PURPOSE: Flavopiridol, a cyclin-dependent kinase inhibitor, has promising clinical activity when combined with chemotherapy. Preclinical data indicate that flavopiridol enhances oxaliplatin (OX)- and fluorouracil (5FU)-induced apoptosis in a sequence-dependent manner. EXPERIMENTAL DESIGN: We conduct...

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Main Authors: Rathkopf, Dana, Dickson, Mark A., Feldman, Darren R., Carvajal, Richard D., Shah, Manish A., Wu, Nian, Lefkowitz, Robert, Gonen, Mithat, Cane, Lauren M., Dials, Heather J., Winkelmann, Jennifer L., Bosl, George J., Schwartz, Gary K.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787644/
https://ncbi.nlm.nih.gov/pubmed/19934304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1502
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