Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

BACKGROUND: Nikkomycins are a group of peptidyl nucleoside antibiotics and act as potent inhibitors of chitin synthases in fungi and insects. Nikkomycin X and Z are the main components produced by Streptomyces ansochromogenes. Of them, nikkomycin Z is a promising antifungal agent with clinical signi...

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Hauptverfasser: Liao, Guojian, Li, Jine, Li, Lei, Yang, Haihua, Tian, Yuqing, Tan, Huarong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787493/
https://ncbi.nlm.nih.gov/pubmed/19930628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-8-61
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