Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4

INTRODUCTION: Interleukin (IL)-17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis (CIA). Interferon(IFN)-γ and IL-4 have been shown to suppress Th17 development in vitro, but their potential immunoregulatory roles in vivo are uncerta...

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Detalhes bibliográficos
Main Authors: Sarkar, Sujata, Cooney, Laura A, White, Peter, Dunlop, Deborah B, Endres, Judith, Jorns, Julie M, Wasco, Matthew J, Fox, David A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787258/
https://ncbi.nlm.nih.gov/pubmed/19852819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2838
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