Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

The main immunogenic region (MIR) is a conformation-dependent region at the extracellular apex of α1 subunits of muscle nicotinic acetylcholine receptor (AChR) that is the target of half or more of the autoantibodies to muscle AChRs in human myasthenia gravis and rat experimental autoimmune myasthen...

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Autores principales: Luo, Jie, Taylor, Palmer, Losen, Mario, de Baets, Marc H., Shelton, G. Diane, Lindstrom, Jon
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787250/
https://ncbi.nlm.nih.gov/pubmed/19890000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2833-09.2009
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