MATURATION-INDUCED DOWNREGULATION OF MFG-E8 IMPAIRS APOPTOTIC CELL CLEARANCE AND ENHANCES ENDOTOXIN RESPONSE

In sepsis, phagocytosis and killing of bacteria by phagocytes are important. Similarly, the clearance of accumulating apoptotic cells is critical in maintaining normal immunity. Upon maturation, peritoneal macrophages (PM) become a major source of proinflammatory cytokines, while losing their effica...

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Bibliografiske detaljer
Main Authors: Miksa, Michael, Amin, Dhruv, Wu, Rongqian, Jacob, Asha, Zhou, Mian, Dong, Weifeng, Yang, Weng-Lang, Ravikumar, Thanjavur S., Wang, Ping
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787083/
https://ncbi.nlm.nih.gov/pubmed/19020771
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