MATURATION-INDUCED DOWNREGULATION OF MFG-E8 IMPAIRS APOPTOTIC CELL CLEARANCE AND ENHANCES ENDOTOXIN RESPONSE

In sepsis, phagocytosis and killing of bacteria by phagocytes are important. Similarly, the clearance of accumulating apoptotic cells is critical in maintaining normal immunity. Upon maturation, peritoneal macrophages (PM) become a major source of proinflammatory cytokines, while losing their effica...

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Autores principales: Miksa, Michael, Amin, Dhruv, Wu, Rongqian, Jacob, Asha, Zhou, Mian, Dong, Weifeng, Yang, Weng-Lang, Ravikumar, Thanjavur S., Wang, Ping
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787083/
https://ncbi.nlm.nih.gov/pubmed/19020771
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