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Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold

Transferases and hydrolases catalyze different chemical reactions and express different dynamic responses upon ligand binding. To insulate the ligand molecule from the surrounding water, transferases bury it inside the protein by closing the cleft, while hydrolases undergo a small conformational cha...

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Bibliographic Details
Main Authors: Koike, Ryotaro, Kidera, Akinori, Ota, Motonori
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786970/
https://ncbi.nlm.nih.gov/pubmed/19670211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.218
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