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Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold
Transferases and hydrolases catalyze different chemical reactions and express different dynamic responses upon ligand binding. To insulate the ligand molecule from the surrounding water, transferases bury it inside the protein by closing the cleft, while hydrolases undergo a small conformational cha...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786970/ https://ncbi.nlm.nih.gov/pubmed/19670211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.218 |
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