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Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold

Transferases and hydrolases catalyze different chemical reactions and express different dynamic responses upon ligand binding. To insulate the ligand molecule from the surrounding water, transferases bury it inside the protein by closing the cleft, while hydrolases undergo a small conformational cha...

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Bibliografiske detaljer
Main Authors: Koike, Ryotaro, Kidera, Akinori, Ota, Motonori
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786970/
https://ncbi.nlm.nih.gov/pubmed/19670211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.218
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