Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

The flavivirus genome comprises a single strand of positive-sense RNA, which is translated into a polyprotein and cleaved by a combination of viral and host proteases to yield functional proteins. One of these, nonstructural protein 3 (NS3), is an enzyme with both serine protease and NTPase/helicase...

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Main Authors: Assenberg, René, Mastrangelo, Eloise, Walter, Thomas S., Verma, Anil, Milani, Mario, Owens, Raymond J., Stuart, David I., Grimes, Jonathan M., Mancini, Erika J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2009
נושאים:
Structure and Assembly
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786852/
https://ncbi.nlm.nih.gov/pubmed/19793813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00942-09
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