PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

When used as therapy for hematopoietic malignancies, allogeneic BM transplantation (BMT) relies on the graft-versus-leukemia (GVL) effect to eradicate residual tumor cells through immunologic mechanisms. However, graft-versus-host disease (GVHD), which is initiated by alloreactive donor T cells that...

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מידע ביבליוגרפי
Main Authors: Valenzuela, Javier O., Iclozan, Cristina, Hossain, Mohammad S., Prlic, Martin, Hopewell, Emily, Bronk, Crystina C., Wang, Junmei, Celis, Esteban, Engelman, Robert W., Blazar, Bruce R., Bevan, Michael J., Waller, Edmund K., Yu, Xue-Zhong, Beg, Amer A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2009
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786796/
https://ncbi.nlm.nih.gov/pubmed/19907075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39692
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