Phenylbutyrate Induces Antimicrobial Peptide Expression

Antimicrobial peptides (AMPs) are important components of our first line of defense. Induction of AMPs such as LL-37 of the cathelicidin family might provide a novel approach in treating bacterial infections. In this study we identified 4-phenylbutyrate (PBA) as a novel inducer of AMP expression and...

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Main Authors: Steinmann, Jonas, Halldórsson, Skarphéđinn, Agerberth, Birgitta, Gudmundsson, Gudmundur H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786349/
https://ncbi.nlm.nih.gov/pubmed/19770273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00818-09
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