Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

CD8(+) T-cells specific for MART-1-(26–35), a dominant melanoma epitope restricted by human leukocyte antigen (HLA)-A*0201, are exceptionally common in the naive T-cell repertoire. Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor α (TCRα) chain in >87% of these T-cells. Here, t...

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Detalles Bibliográficos
Main Authors: Cole, David K., Yuan, Fang, Rizkallah, Pierre J., Miles, John J., Gostick, Emma, Price, David A., Gao, George F., Jakobsen, Bent K., Sewell, Andrew K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785656/
https://ncbi.nlm.nih.gov/pubmed/19605354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022509
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