Minute Time Scale Prolyl Isomerization Governs Antibody Recognition of an Intrinsically Disordered Immunodominant Epitope

Conformational rearrangements in antibody·antigen recognition are essential events where kinetic discrimination of isomers expands the universe of combinations. We investigated the interaction mechanism of a monoclonal antibody, M1, raised against E7 from human papillomavirus, a prototypic viral onc...

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Bibliografiska uppgifter
Huvudupphovsmän: Fassolari, Marisol, Chemes, Lucia B., Gallo, Mariana, Smal, Clara, Sánchez, Ignacio E., de Prat-Gay, Gonzalo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Molecular Biophysics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642352/
https://ncbi.nlm.nih.gov/pubmed/23504368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444554
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