Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4α

The SIRT1 activators isonicotinamide (IsoNAM), resveratrol, fisetin, and butein repressed transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). An evolutionarily conserved binding site for hepatic nuclear factor (HNF) 4α (−272/−252) was identified, wh...

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Hlavní autoři: Yang, Jianqi, Kong, Xiaoying, Martins-Santos, Maria Emilia S., Aleman, Gabriela, Chaco, Ernestine, Liu, George E., Wu, Shwu-Yuan, Samols, David, Hakimi, Parvin, Chiang, Cheng-Ming, Hanson, Richard W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Transcription, Chromatin, and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785634/
https://ncbi.nlm.nih.gov/pubmed/19651778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047340
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